RT Journal Article
T1 Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients.
A1 Moreno-Indias, Isabel
A1 Sanchez-Alcoholado, Lidia
A1 Perez-Martinez, Pablo
A1 Andres-Lacueva, Cristina
A1 Cardona, Fernando
A1 Tinahones, Francisco
A1 Queipo-Ortuño, Maria Isabel
K1 Bacteria
K1 Biomarkers
K1 Feces
K1 Gastrointestinal microbiome
K1 Gastrointestinal tract
AB This study evaluated the possible prebiotic effect of a moderate intake of red wine polyphenols on the modulation of the gut microbiota composition and the improvement in the risk factors for the metabolic syndrome in obese patients. Ten metabolic syndrome patients and ten healthy subjects were included in a randomized, crossover, controlled intervention study. After a washout period, the subjects consumed red wine and de-alcoholized red wine over a 30 day period for each. The dominant bacterial composition did not differ significantly between the study groups after the two red wine intake periods. In the metabolic syndrome patients, red wine polyphenols significantly increased the number of fecal bifidobacteria and Lactobacillus (intestinal barrier protectors) and butyrate-producing bacteria (Faecalibacterium prausnitzii and Roseburia) at the expense of less desirable groups of bacteria such as LPS producers (Escherichia coli and Enterobacter cloacae). The changes in gut microbiota in these patients could be responsible for the improvement in the metabolic syndrome markers. Modulation of the gut microbiota by using red wine could be an effective strategy for managing metabolic diseases associated with obesity.
PB Royal Society of Chemistry
YR 2016
FD 2016
LK http://hdl.handle.net/10668/9631
UL http://hdl.handle.net/10668/9631
LA en
NO Moreno-Indias I, Sánchez-Alcoholado L, Pérez-Martínez P, Andrés-Lacueva C, Cardona F, Tinahones F, et al. Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. Food Funct. 2016 Apr;7(4):1775-87
DS RISalud
RD Apr 12, 2025