RT Journal Article
T1 Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea.
A1 Santamaria-Martos, Fernando
A1 Benítez, Ivan
A1 Girón, Cristina
A1 Barbé, Ferran
A1 Martínez-García, Miguel-Angel
A1 Hernández, Luis
A1 Montserrat, Josep M
A1 Nagore, Eduardo
A1 Martorell, Antonio
A1 Campos-Rodriguez, Francisco
A1 Corral, Jaime
A1 Cabriada, Valentin
A1 Abad, Jorge
A1 Mediano, Olga
A1 Troncoso, Maria F
A1 Cano-Pumarega, Irene
A1 Fortuna Gutierrez, Ana Maria
A1 Diaz-Cambriles, Trinidad
A1 Somoza-Gonzalez, Maria
A1 Almendros, Isaac
A1 Farre, Ramon
A1 Gozal, David
A1 Sánchez-de-la-Torre, Manuel
A1 Spanish Sleep Network, 
AB The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI) 0-5 events·h-1), mild OSA (AHI 5-15 events·h-1) and moderate-severe OSA (AHI >15 events·h-1). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8-68.0) years and AHI 8.55 (2.8-19.5) events·h-1). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion.
YR 2018
FD 2018-03-15
LK http://hdl.handle.net/10668/12221
UL http://hdl.handle.net/10668/12221
LA en
DS RISalud
RD Apr 6, 2025