%0 Journal Article
%A Santamaria-Martos, Fernando
%A Benítez, Ivan
%A Girón, Cristina
%A Barbé, Ferran
%A Martínez-García, Miguel-Angel
%A Hernández, Luis
%A Montserrat, Josep M
%A Nagore, Eduardo
%A Martorell, Antonio
%A Campos-Rodriguez, Francisco
%A Corral, Jaime
%A Cabriada, Valentin
%A Abad, Jorge
%A Mediano, Olga
%A Troncoso, Maria F
%A Cano-Pumarega, Irene
%A Fortuna Gutierrez, Ana Maria
%A Diaz-Cambriles, Trinidad
%A Somoza-Gonzalez, Maria
%A Almendros, Isaac
%A Farre, Ramon
%A Gozal, David
%A Sánchez-de-la-Torre, Manuel
%A Spanish Sleep Network
%T Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea.
%D 2018
%U http://hdl.handle.net/10668/12221
%X The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI) 0-5 events·h-1), mild OSA (AHI 5-15 events·h-1) and moderate-severe OSA (AHI >15 events·h-1). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8-68.0) years and AHI 8.55 (2.8-19.5) events·h-1). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion.
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