RT Generic
T1 Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment.
A1 Skwierawska, Dominika
A1 Lopez-Valverde, Jose Antonio
A1 Balcerzyk, Marcin
A1 Leal, Antonio
K1 BNCT
K1 biological dosimetry
K1 boron imaging
K1 personalized medicine
K1 personalized oncology
K1 targeted therapy
AB Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.
PB MDPI AG
SN 2072-6694
YR 2022
FD 2022-06-10
LK http://hdl.handle.net/10668/20902
UL http://hdl.handle.net/10668/20902
LA en
NO Skwierawska D, López-Valverde JA, Balcerzyk M, Leal A. Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. Cancers (Basel). 2022 Jun 10;14(12):2865.
DS RISalud
RD Apr 18, 2025