%0 Journal Article
%A Rodríguez-Izquierdo, I
%A Serramía, M J
%A Gómez, R
%A Espinosa, G
%A Genebat, M
%A Leal, M
%A Muñoz-Fernandez, M A
%T Safety and efficacy of G2-S16 dendrimer as microbicide in healthy human vaginal tissue explants.
%D 2022
%U http://hdl.handle.net/10668/20323
%X The absence of an effective treatment and vaccine in HIV-1 pandemic place preventive strategies such as safety and effective microbicide development as a central therapeutic approach to control HIV-1 pandemic nowadays. Studies of cytotoxicity, immune population status, inflammation or tissue damage and mainly prophylactic inhibition of HIV-1 infection in vaginal human explants demonstrate the biosafety and effectivity of G2-S16 dendrimer. Human explants treated with G2-S16 dendrimer or treated and HIV-1 infected do not presented signs of irritation, inflammation, immune activation or T cell populations deregulation. Herein we conclude that G2-S16 dendrimer has demonstrated sufficient efficacy, biosafety, effectivity and behavior in the closest to the real-life condition model represented by the human healthy donor vaginal tissue explants, to raise G2-S16 dendrimer as a promising candidate to clinical trials to develop an effective microbicide against HIV-1 infection.
%K Efficacy
%K G2-S16
%K HIV-1
%K Microbicide
%K Safety
%K Vaginal explants
%~