RT Journal Article
T1 Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain).
A1 Sanbonmatsu-Gamez, Sara
A1 Pedrosa-Corral, Irene
A1 Navarro-Mari, Jose Maria
A1 Perez-Ruiz, Mercedes
K1 RT-PCR
K1 Spain
K1 Toscana virus
K1 automation
K1 encephalitis
K1 meningitis
AB The sandfly fever Toscana virus (TOSV, genus Phlebovirus, family Phenuiviridae) is endemic in Mediterranean countries. In Spain, phylogenetic studies of TOSV strains demonstrated that a genotype, different from the Italian, was circulating. This update reports 107 cases of TOSV neurological infection detected in Andalusia from 1988 to 2020, by viral culture, serology and/or RT-PCR. Most cases were located in Granada province, a hyperendemic region. TOSV neurological infection may be underdiagnosed since few laboratories include this virus in their portfolio. This work presents a reliable automated method, validated for the detection of the main viruses involved in acute meningitis and encephalitis, including the arboviruses TOSV and West Nile virus. This assay solves the need for multiple molecular platforms for different viruses and thus, improves the time to results for these syndromes, which require a rapid and efficient diagnostic approach.
PB MDPI AG
YR 2021
FD 2021-07-19
LK http://hdl.handle.net/10668/18477
UL http://hdl.handle.net/10668/18477
LA en
NO Sanbonmatsu-Gámez S, Pedrosa-Corral I, Navarro-Marí JM, Pérez-Ruiz M. Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain). Viruses. 2021 Jul 23;13(8):1438
DS RISalud
RD Apr 7, 2025