TY  - JOUR
AU  - Rubio-Ruiz, Belen
AU  - Serran-Aguilera, Lucia
AU  - Hurtado-Guerrero, Ramon
AU  - Conejo-Garcia, Ana
PY  - 2020
DO  - 10.1002/med.21746
UR  - http://hdl.handle.net/10668/16476
T2  - Medicinal research reviews
AB  - Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho), is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme responsible for PCho synthesis, has consequently become a promising drug...
LA  - en
PB  - John Wiley & Sons, Inc.
KW  - cancer
KW  - choline kinase
KW  - inhibitors
KW  - malaria
KW  - structure-based drug design
KW  - Binding Sites
KW  - Cell Transformation, Neoplastic
KW  - Choline Kinase
KW  - Enzyme Inhibitors
KW  - Humans
TI  - Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition.
TY  - research article
VL  - 41
ER  -