RT Journal Article
T1 Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder.
A1 Galván, Sandra Torres
A1 Flores-López, María
A1 Romero-Sanchiz, Pablo
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Nogueira-Arjona, Raquel
A1 Mayoral, Fermín
A1 Araos, Pedro
A1 Serrano, Antonia
A1 Muga, Roberto
A1 Pavón, Francisco Javier
A1 García-Marchena, Nuria
A1 de Fonseca, Fernando Rodríguez
AB Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = - 0.233, p 
YR 2021
FD 2021-07-01
LK http://hdl.handle.net/10668/18139
UL http://hdl.handle.net/10668/18139
LA en
DS RISalud
RD Apr 18, 2025