RT Journal Article
T1 Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder.
A1 Torres-Galvan, Sandra
A1 Flores-Lopez, Maria
A1 Romero-Sanchiz, Pablo
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Nogueira-Arjona, Raquel
A1 Mayoral, Fermin
A1 Araos, Pedro
A1 Serrano, Antonia
A1 Muga, Roberto
A1 Pavon, Francisco Javier
A1 Garcia-Marchena, Nuria
A1 Rodriguez-de-Fonseca, Fernando
K1 Alcoholism
K1 Cocaine-Related Disorders
K1 Comorbidity
K1 Depressive Disorder, Major
AB Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = - 0.233, p < 0.001) but not in the patients with MDD. G‑CSF concentrations were lower in patients with SUD than in controls (p < 0.05), specifically in the cocaine subgroup (p < 0.05). Patients with SUD and comorbid MDD had lower G‑CSF concentrations than patients with SUD but not comorbid MDD or controls (p < 0.05). In contrast, patients with MDD but not SUD showed no differences compared with their controls. The negative association between G‑CSF concentrations and age in the sample was not observed in patients with MDD. G‑CSF concentrations were decreased in patients with SUD and comorbid MDD but not in patients with MDD. Therefore, G‑CSF may be useful to improve the stratification of patients with dual diagnosis seeking treatment. Further investigation is needed to explore the impact of sex and type of drug on the expression of G‑CSF.
PB Nature Publishing Group
YR 2021
FD 2021-07-01
LK http://hdl.handle.net/10668/18139
UL http://hdl.handle.net/10668/18139
LA en
NO Galván ST, Flores-López M, Romero-Sanchiz P, Requena-Ocaña N, Porras-Perales O, Nogueira-Arjona R, et al. Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder. Sci Rep. 2021 Jul 1;11(1):13629
DS RISalud
RD Aug 6, 2025