RT Journal Article
T1 Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis
A1 López-Mejías, Raquel
A1 Corrales, Alfonso
A1 Vicente, Esther
A1 Robustillo-Villarino, Montserrat
A1 González-Juanatey, Carlos
A1 Llorca, Javier
A1 Genre, Fernanda
A1 Remuzgo-Martínez, Sara
A1 Dierssen-Sotos, Trinidad
A1 Miranda-Filloy, José A
A1 Ramírez Huaranga, Marco A
A1 Pina, Trinitario
A1 Blanco, Ricardo
A1 Alegre-Sancho, Juan J
A1 Raya, Enrique
A1 Mijares, Verónica
A1 Ubilla, Begoña
A1 Ferraz-Amaro, Iván
A1 Gómez-Vaquero, Carmen
A1 Balsa, Alejandro
A1 López-Longo, Francisco J
A1 Carreira, Patricia
A1 González-Álvaro, Isidoro
A1 Ocejo-Vinyals, J Gonzalo
A1 Rodríguez-Rodríguez, Luis
A1 Fernández-Gutiérrez, Benjamín
A1 Castañeda, Santos
A1 Martín, Javier
A1 González-Gay, Miguel A
K1 Artritis reumatoide
K1 Aterosclerosis
K1 Enfermedades cardiovasculares
K1 Grosor intima-media carotídeo
K1 Enfermedad de la arteria coronaria
K1 Genotipo
K1 Humanos
K1 Polimorfismo genético
K1 Estados Unidos
K1 Europa (Continente)
AB A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
PB Nature Publishing Group
YR 2017
FD 2017-01-06
LK http://hdl.handle.net/10668/2632
UL http://hdl.handle.net/10668/2632
LA en
NO López-Mejías R, Corrales A, Vicente E, Robustillo-Villarino M, González-Juanatey C, Llorca J, et al. Influence of coronary artery disease and subcClinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis. Sci Rep. 2017; 7:40303
NO This study was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060 and PI15/00525) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009 (RIER) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain), and in part by grants from the European IMI BTCure Program. RL-M and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013). FG is a recipient of a Sara Borrell postdoctoral fellowship from the “Instituto Carlos III de Salud” at the Spanish Ministry of Health (Spain) (CD15/00095).
DS RISalud
RD Apr 8, 2025