RT Journal Article
T1 Associations of major depressive disorder with chronic physical conditions, obesity and medication use: Results from the PISMA-ep study.
A1 Rivera, Margarita
A1 Porras-Segovia, Alejandro
A1 Rovira, Paula
A1 Molina, Esther
A1 Gutiérrez, Blanca
A1 Cervilla, Jorge
K1 Antidepressant
K1 Epidemiology
K1 Gender
K1 Pain
K1 Psychiatry in Europe
K1 Unipolar depression
AB Life expectancy of people with depression is on average 15 years less than that of the general population. This excess of mortality is largely attributed to a deteriorated physical health. Evidence about the association between major depressive disorder (MDD) and physical health is still lacking in some areas. The aim of this study was to explore the association between MDD and physical health-related variables in southern Spain. The PISMA-ep is a cross-sectional study based on community-dwelling adult population. Our main outcome was current prevalence of MDD. Independent variables explored were: lifetime prevalence of twenty-one chronic physical conditions (CPCs), anthropometric measures (height, weight, body max index, and hip and waist circumferences), general health status, and medication use. MDD was significantly associated with any CPC (OR = 2.60; 95% CI: 2.01-3.35; p  MDD is associated with CPCs, obesity, and increased use of medication. The high rates of comorbidity between MDD and CPCs call for a more holistic management of patients in the clinical practice. The low rate of antidepressant use may be indicating underdiagnosis. Anthropometric variables were differently associated with MDD depending on gender, suggesting a strong influence of psychosocial factors.
YR 2019
FD 2019-05-14
LK http://hdl.handle.net/10668/13977
UL http://hdl.handle.net/10668/13977
LA en
DS RISalud
RD Apr 12, 2025