%0 Journal Article
%A Faura, Júlia
%A Ramiro, Laura
%A Simats, Alba
%A Ma, Feifei
%A Penalba, Anna
%A Gasull, Teresa
%A Rosell, Anna
%A Montaner, Joan
%A Bustamante, Alejandro
%T Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia.
%D 2022
%U http://hdl.handle.net/10668/21178
%X After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performed transient middle cerebral artery occlusion (MCAO) and sham surgery on C57BL/6J mice and collected bronchoalveolar lavage fluid (BALF), serum, brain, and lung homogenate samples 24 h after surgery. A 92 proteins-panel developed by Olink Proteomics® was used to analyze the content in BALF and lung homogenates. MCAO animals had higher protein concentration levels in BALF than sham-controls, but these levels did not correlate with the infarct volume. No alteration in alveolar-capillary barrier permeability was observed. A total of 12 and 14 proteins were differentially expressed between the groups (FDR
%K inflammation
%K pulmonary complications
%K stroke
%~