RT Journal Article
T1 KIR+ CD8+ T Lymphocytes in Cancer Immunosurveillance and Patient Survival: Gene Expression Profiling
A1 Gimeno, Lourdes
A1 Serrano-López, Emilio M.
A1 Campillo, José A.
A1 Cánovas-Zapata, María A.
A1 Acuña, Omar S.
A1 García-Cózar, Francisco
A1 Martínez-Sánchez, María V.
A1 Martínez-Hernández, María D.
A1 Soto-Ramírez, María F.
A1 López-Cubillana, Pedro
A1 Martínez-Escribano, Jorge
A1 Martínez-García, Jerónimo
A1 Corbalan-García, Senena
A1 Álvarez-López, María R.
A1 Minguela, Alfredo
K1 Cancer
K1 CD8+T
K1 Cells
K1 KIR
K1 Immunosurveillance
K1 Gene expression
K1 Microarray
K1 T Lymphocytes
K1 Tumor microenvironment
K1 Neoplasias
K1 Células
K1 Linfocitos T
K1 Receptores KIR
K1 Vigilancia inmunológica
K1 Expresión génica
K1 Análisis de secuencia por matrices de oligonucleótidos
K1 Microambiente tumoral
AB Killer-cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) and effector T cells. Although KIR+ T cells accumulate in oncologic patients, their role in cancer immune response remains elusive. This study explored the role of KIR+CD8+ T cells in cancer immunosurveillance by analyzing their frequency at diagnosis in the blood of 249 patients (80 melanomas, 80 bladder cancers, and 89 ovarian cancers), their relationship with overall survival (OS) of patients, and their gene expression profiles. KIR2DL1+ CD8+ T cells expanded in the presence of HLA-C2-ligands in patients who survived, but it did not in patients who died. In contrast, presence of HLA-C1-ligands was associated with dose-dependent expansions of KIR2DL2/S2+ CD8+ T cells and with shorter OS. KIR interactions with their specific ligands profoundly impacted CD8+ T cell expression profiles, involving multiple signaling pathways, effector functions, the secretome, and consequently, the cellular microenvironment, which could impact their cancer immunosurveillance capacities. KIR2DL1/S1+ CD8+ T cells showed a gene expression signature related to efficient tumor immunosurveillance, whereas KIR2DL2/L3/S2+CD8+ T cells showed transcriptomic profiles related to suppressive anti-tumor responses. These results could be the basis for the discovery of new therapeutic targets so that the outcome of patients with cancer can be improved.
PB MDPI
YR 2020
FD 2020-10-15
LK http://hdl.handle.net/10668/4553
UL http://hdl.handle.net/10668/4553
LA en
NO Gimeno L, Serrano-López EM, Campillo JA, Cánovas-Zapata MA, Acuña OS, García-Cózar F, et al. KIR+ CD8+ T Lymphocytes in Cancer Immunosurveillance and Patient Survival: Gene Expression Profiling. Cancers. 2020 Oct 15;12(10):2991
DS RISalud
RD Apr 19, 2025