RT Journal Article
T1 Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use
A1 Jimenez-Puerta, Gonzalo José
A1 Marchal, Juan Antonio
A1 López-Ruiz, Elena
A1 Gálvez-Martín, Patricia
K1 Mesenchymal stromal cells
K1 Mechanism of action
K1 Homing
K1 Immunomodulation
K1 Células madre mesenquimatosas
K1 Movimiento celular
K1 Células
K1 Tejidos
AB Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or systemically into the receptor body where they can traffic and migrate towards the affected tissue and participate in the process of healing. The therapeutic effects of MSCs compromise of different mechanisms such as the functional integration of differentiated MSCs into diseased host tissue after transplantation, their paracrine support, and their impact on the regulation of both the innate and the acquired immune system. Here, we establish and provide recent advances about the principal mechanisms of action through which MSCs can perform their activity and effect as a therapeutic tool. The purpose of this review is to examine and discuss the MSCs capacity of migration, their paracrine effect, as well as MSC-mediated modifications on immune cell responses.
PB MDPI
YR 2020
FD 2020-02-06
LK http://hdl.handle.net/10668/3758
UL http://hdl.handle.net/10668/3758
LA en
NO Jimenez-Puerta GJ, Marchal JA, López-Ruiz E, Gálvez-Martín P. Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use. J Clin Med. 2020 Feb 6;9(2):445
DS RISalud
RD Apr 9, 2025