RT Journal Article
T1 Immunological features beyond CD4/CD8 ratio values in older individuals.
A1 Garrido-Rodríguez, Vanesa
A1 Herrero-Fernández, Inés
A1 Castro, María José
A1 Castillo, Ana
A1 Rosado-Sánchez, Isaac
A1 Galvá, María Isabel
A1 Ramos, Raquel
A1 Olivas-Martínez, Israel
A1 Bulnes-Ramos, Ángel
A1 Cañizares, Julio
A1 Leal, Manuel
A1 Pacheco, Yolanda María
K1 CD4/CD8 T-cell ratio
K1 TREC
K1 Treg
K1 inflammation
K1 thymic output
AB The CD4/CD8 T-cell ratio is emerging as a relevant marker of evolution for many pathologies and therapies. We aimed to explore immunological features beyond CD4/CD8 ratio values in older subjects (>65 years old) who were classified as having lower (65 years old) who were classified as having lower (2) ratio values. The lower group showed a lower thymic output (sj/β-TREC ratio) and frequency of naïve T-cells, concomitant with increased mature T-cells. In these subjects, the CD4 T-cell subset was enriched in CD95+ but depleted of CD98+ cells. The regulatory T-cell (Treg) compartment was enriched in CTLA-4+ cells. The CD8 T-cell pool exhibited increased frequencies of CD95+ cells but decreased frequencies of integrin-β7+ cells. Interestingly, in the intermediate group, the CD4 pool showed greater differences than the CD8 pool, mostly for cellular senescence. Regarding inflammation, only hsCRP was elevated in the lower group; however, negative correlations between the CD4/CD8 ratio and β2-microglobulin and sCD163 were detected. These subjects displayed trends of more comorbidities and less independence in daily activities. Altogether, our data reveal different thymic output and immune profiles for T-cells across CD4/CD8 ratio values that can define immune capabilities, affecting health status in older individuals. Thus, the CD4/CD8 ratio may be used as an integrative marker of biological age.
YR 2021
FD 2021-05-26
LK http://hdl.handle.net/10668/17835
UL http://hdl.handle.net/10668/17835
LA en
DS RISalud
RD Apr 10, 2025