RT Journal Article
T1 Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population
A1 Mansego, Maria Luisa
A1 Martínez, Fernando
A1 Martínez-Larrad, Maria Teresa
A1 Zabena, Carina
A1 Rojo, Gemma
A1 Morcillo, Sonsoles
A1 Soriguer, Federico
A1 Martín-Escudero, Juan Carlos
A1 Serrano-Ríos, Manuel
A1 Redon, Josep
A1 Chaves, Felipe Javier
K1 Adulto
K1 Resistencia a la Insulina
K1 Diabetes Mellitus Tipo 2
K1 Variación Genética
K1 Análisis de Regresión
K1 Factores de Riesgo
K1 España
AB SUMMARYThe main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.METHODS1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.RESULTSOne polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population.CONCLUSIONSThe study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians.
PB Public Library of Science
YR 2012
FD 2012-03-02
LK http://hdl.handle.net/10668/827
UL http://hdl.handle.net/10668/827
LA en
NO Mansego ML, Martínez F, Martínez-Larrad MT, Zabena C, Rojo G, Morcillo S, et al. Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population. PLoS ONE. 2012; 7(3):e31853
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025