RT Journal Article
T1 Magnetization Transfer BOOST Noncontrast Angiography Improves Pulmonary Vein Imaging in Adults With Congenital Heart Disease.
A1 Rashid, Imran
A1 Ginami, Giulia
A1 Nordio, Giovanna
A1 Fotaki, Anastasia
A1 Neji, Radhouene
A1 Alam, Harith
A1 Pushparajah, Kuberan
A1 Frigiola, Alessandra
A1 Valverde, Israel
A1 Botnar, Rene M
A1 Prieto, Claudia
K1 3D whole heart imaging
K1 MTC-BOOST
K1 congenital heart disease
K1 magnetization Transfer
AB Cardiac MRI plays an important role in the diagnosis and follow-up of patients with congenital heart disease (CHD). Gadolinium -based contrast agents are often needed to overcome flow-related and off-resonance artifacts that can impair the quality of conventional noncontrast 3D imaging. As serial imaging is often required in CHD, the development of robust noncontrast 3D MRI techniques is desirable.PurposeTo assess the clinical utility of noncontrast enhanced magnetization transfer and inversion recovery prepared 3D free- breathing sequence (MTC-BOOST) compared to conventional 3D whole heart imaging in patients with CHD.Study typeProspective, image quality.PopulationA total of 27 adult patients (44% female , mean age 30.9 ± 14.8 years) with CHD.Field Strength/SequenceA 1.5 T; free- breathing 3D MTC-BOOST sequence.AssessmentMTC-BOOST was compared to diaphragmatic navigator-gated, noncontrast T2 prepared 3D whole- heart imaging sequence (T2prep-3DWH) for comparison of vessel dimensions, lumen-to- myocardium contrast ratio (CR), and image quality (vessel wall sharpness and presence and type of artifacts ) assessed by two experienced cardiologists on a 5-point scale.Statistical TestsMann–Whitney test, paired Wilcoxon signed-rank test, Bland–Altman plots. P < 0.05 was considered statistically significant.ResultsMTC-BOOST significantly improved image quality and CR of the right-sided pulmonary veins (PV): (CR: right upper PV 1.06 ± 0.50 vs. 0.58 ± 0.74; right lower PV 1.32 ± 0.38 vs. 0.81 ± 0.73) compared to conventional T2prep-3DWH imaging where the PVs were not visualized in some cases due to off-resonance effects. MTC-BOOST demonstrated resistance to degradation of luminal signal (assessed by CR) secondary to accelerated or turbulent flow conditions. T2prep-3DWH had higher image quality scores than MTC-BOOST for the aorta and coronary arteries ; however, great vessel dimensions derived from MTC-BOOST showed excellent agreement with standard T2prep-3DWH imaging.Data ConclusionMTC-BOOST allows for improved contrast-free imaging of pulmonary veins and regions characterized by accelerated or turbulent blood flow compared to standard T2prep-3DWH imaging, with excellent agreement of great vessel dimensions.
PB John Wiley & Sons, Inc.
YR 2023
FD 2023-01-17
LK http://hdl.handle.net/10668/22206
UL http://hdl.handle.net/10668/22206
LA en
NO Rashid I, Ginami G, Nordio G, Fotaki A, Neji R, Alam H, et al. Magnetization Transfer BOOST Noncontrast Angiography Improves Pulmonary Vein Imaging in Adults With Congenital Heart Disease. J Magn Reson Imaging. 2023 Feb;57(2):521-531
DS RISalud
RD Jul 30, 2025