RT Journal Article
T1 Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review.
A1 Llamas-Molina, Jose Maria
A1 Carrero-Castaño, Alejandro
A1 Ruiz-Villaverde, Ricardo
A1 Campos, Antonio
K1 androgenetic alopecia
K1 bioengineering
K1 hair follicle
K1 regenerative medicine
K1 tissue engineering
AB Androgenetic alopecia (AGA) is an androgen-dependent process and represents the most frequent non-scarring alopecia. Treatments for AGA do not always achieve a satisfactory result for the patient, and sometimes cause side effects that lead to discontinuation of treatment. AGA therapeutics currently includes topical and oral drugs, as well as follicular unit micro-transplantation techniques. Tissue engineering (TE) is postulated as one of the possible future solutions to the problem and aims to develop fully functional hair follicles that maintain their cyclic rhythm in a physiological manner. However, despite its great potential, reconstitution of fully functional hair follicles is still a challenge to overcome and the knowledge gained of the key processes in hair follicle morphogenesis and biology has not yet been translated into effective replacement therapies in clinical practice. To achieve this, it is necessary to research and develop new approaches, techniques and biomaterials. In this review, present and emerging hair follicle bioengineering strategies are evaluated. The current problems of these bioengineering techniques are discussed, as well as the advantages and disadvantages, and the future prospects for the field of TE and successful hair follicle regeneration.
PB MDPI AG
SN 2075-1729
YR 2022
FD 2022-01-08
LK http://hdl.handle.net/10668/21393
UL http://hdl.handle.net/10668/21393
LA en
NO Llamas-Molina JM, Carrero-Castaño A, Ruiz-Villaverde R, Campos A. Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review. Life (Basel). 2022 Jan 14;12(1):117.
DS RISalud
RD Apr 7, 2025