RT Journal Article
T1 Clinical and immunological aspects of microRNAs in neonatal sepsis.
A1 Fatmi, Ahlam
A1 Chabni, Nafissa
A1 Cernada, Maria
A1 Vento, Maximo
A1 Gonzalez-Lopez, Maria
A1 Aribi, Mourad
A1 Pallardo, Federico V
A1 Garcia-Gimenez, Jose Luis
K1 Epigenetic changes
K1 Immunity
K1 Inflammation
K1 MicroRNAs
K1 Neonatal sepsis
AB Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regulation by short non-coding RNAs (e.g., microRNAs) have recently acquired special relevance because of their role in the regulation of the pathophysiology of sepsis and their potential clinical use as biomarkers. ~22-nucleotide of microRNAs are not only involved in regulating multiple relevant cellular and molecular functions, such as immune cell function and inflammatory response, but have also been proposed as good candidates as biomarkers in sepsis. Nevertheless, establishing clinical practice guidelines based on microRNA patterns as biomarkers for diagnosis and prognosis in neonatal sepsis has yet to be achieved. Given their differential expression across tissues in neonates, the release of specific microRNAs to blood and their expression pattern can differ compared to sepsis in adult patients. Further in-depth research is necessary to fully understand the biological relevance of microRNAs and assess their potential use in clinical settings. This review provides a general overview of microRNAs, their structure, function and biogenesis before exploring their potential clinical interest as diagnostic and prognostic biomarkers of neonatal sepsis. An important part of the review is focused on immune and inflammatory aspects of selected microRNAs that may become biomarkers for clinical use and therapeutic intervention.
PB Elsevier
YR 2021
FD 2021-11-19
LK http://hdl.handle.net/10668/22036
UL http://hdl.handle.net/10668/22036
LA en
NO Fatmi A, Chabni N, Cernada M, Vento M, González-López M, Aribi M, et al.  Clinical and immunological aspects of microRNAs in neonatal sepsis. Biomed Pharmacother. 2022 Jan;145:112444
NO This work was supported by AES from the Spanish Institute of Health Carlos III grant numbers [AES2019, PI19/00994; PFIS grant FI18/0131] co-financed by the European Regional Development Fund (ERDF); RETICS grant number [PN 2018-2021]; ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (FEDER) grant number [RD16/0022] and the Spanish Institute of Health Carlos III through CIBERer (Biomedical Network Research Center on Rare Diseases) grant number [ACCI2018-09], Fundación Mútua Madrileña (AP174352020) and the Direction Générale de la Recherche Scientifique et du Développement Technologique, MESRS, Algeria.
DS RISalud
RD Apr 5, 2025