RT Journal Article
T1 Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
A1 Yu, Edward
A1 Ruiz-Canela, Miguel
A1 Razquin, Cristina
A1 Guasch-Ferré, Marta
A1 Toledo, Estefania
A1 Wang, Dong D
A1 Papandreou, Christopher
A1 Dennis, Courtney
A1 Clish, Clary
A1 Liang, Liming
A1 Bullo, Monica
A1 Corella, Dolores
A1 Fitó, Montserrat
A1 Gutiérrez-Bedmar, Mario
A1 Lapetra, José
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Cofán, Montserrat
A1 Arós, Fernando
A1 Romaguera, Dora
A1 Serra-Majem, Lluis
A1 Sorlí, Jose V
A1 Salas-Salvadó, Jordi
A1 Hu, Frank B
A1 Martínez-González, Miguel A
K1 cohort study
K1 dietary intervention
K1 insulin resistance
K1 observational study
K1 population study, type 2 diabetes
AB The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
YR 2018
FD 2018-10-02
LK http://hdl.handle.net/10668/12873
UL http://hdl.handle.net/10668/12873
LA en
DS RISalud
RD Apr 7, 2025