%0 Journal Article
%A Yu, Edward
%A Ruiz-Canela, Miguel
%A Razquin, Cristina
%A Guasch-Ferré, Marta
%A Toledo, Estefania
%A Wang, Dong D
%A Papandreou, Christopher
%A Dennis, Courtney
%A Clish, Clary
%A Liang, Liming
%A Bullo, Monica
%A Corella, Dolores
%A Fitó, Montserrat
%A Gutiérrez-Bedmar, Mario
%A Lapetra, José
%A Estruch, Ramón
%A Ros, Emilio
%A Cofán, Montserrat
%A Arós, Fernando
%A Romaguera, Dora
%A Serra-Majem, Lluis
%A Sorlí, Jose V
%A Salas-Salvadó, Jordi
%A Hu, Frank B
%A Martínez-González, Miguel A
%T Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
%D 2018
%U http://hdl.handle.net/10668/12873
%X The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
%K cohort study
%K dietary intervention
%K insulin resistance
%K observational study
%K population study, type 2 diabetes
%~