TY - JOUR AU - Rico-Llanos, Gustavo AU - Porras-Perales, Oscar AU - Escalante, Sandra AU - Vazquez-Calero, Daniel B AU - Valiente, Lucia AU - Castillo, Maria I AU - Perez-Tejeiro, Jose Miguel AU - Baglietto-Vargas, David AU - Becerra, Jose AU - Reguera, Jose Maria AU - Duran, Ivan AU - Csukasi, Fabiana PY - 2022 DO - 10.3389/fimmu.2022.1054962 UR - http://hdl.handle.net/10668/20598 T2 - Frontiers in immunology AB - Inflammation is a central pathogenic feature of the acute respiratory distress syndrome (ARDS) in COVID-19. Previous pathologies such as diabetes, autoimmune or cardiovascular diseases become risk factors for the severe hyperinflammatory syndrome. A... LA - en PB - Frontiers Researcch Foundation KW - 4-PBA KW - COVID-19 KW - TNFa KW - Acute respiratory distress syndrome KW - Binding-immunoglobulinprotein (BiP/GRP78/HSPA5) KW - Cell surface GRP78 (csGRP78) KW - Cellular stress KW - Cytokine storm KW - Humans KW - COVID-19 KW - SARS-CoV-2 KW - Respiratory Distress Syndrome KW - Inflammation KW - Endoplasmic Reticulum Chaperone BiP KW - Lung TI - Cellular stress modulates severity of the inflammatory response in lungs via cell surface BiP. TY - research article VL - 13 ER -