RT Journal Article
T1 Modulation of Telomere Length by Mediterranean Diet, Caloric Restriction, and Exercise: Results from PREDIMED-Plus Study
A1 Fernandez de la Puente, Maria
A1 Hernandez-Alonso, Pablo
A1 Canudas, Silvia
A1 Marti, Amelia
A1 Fito, Montserrat
A1 Razquin, Cristina
A1 Salas-Salvado, Jordi
K1 Mediterranean diet
K1 telomere length
K1 8-hydroxydeoxyguanosine (8-OHdG)
K1 Health
K1 Nutrition
K1 Hallmarks
K1 Validity
AB Telomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our aim was to analyse the effect of an energy-restricted MedDiet with physical activity promotion (intervention group) versus an unrestricted-caloric MedDiet with no weight-loss advice (control group) on TL and 8-hydroxydeoxyguanosine (8-OHdG) plasma levels. In total, 80 non-diabetic participants with metabolic syndrome were randomly selected from the PREDIMED (PREvencion con DIeta MEDiterranea)-Plus-Reus study. TL was measured by a hybridisation method and 8-OHdG levels by ELISA at baseline and after one year of intervention. Linear mixed models (LMM)-raw and after adjusting for potential confounders-were used to examine the associations between TL or 8-OHdG plasma levels by intervention group and/or time. A total of 69 subjects with available DNA samples were included in the analyses. A significant beta-coefficient was found for time towards increasing values through the year of follow-up for TL (unadjusted beta of 0.740 (95% CI: 0.529 to 0.951), and multivariable model beta of 0.700 (95% CI: 0.477 to 0.922)). No significant beta s were found, neither for the intervention group nor for the interaction between the intervention group and time. Regarding 8-OHdG plasma levels, no significant beta s were found for the intervention group, time, and its interaction. Our results suggest that MedDiet could have an important role in preventing telomere shortening, but calorie restriction and exercise promotion did not provide an additional advantage concerning telomere length after one year of MedDiet intervention.
PB Mdpi
YR 2021
FD 2021-10-01
LK https://hdl.handle.net/10668/26974
UL https://hdl.handle.net/10668/26974
LA en
DS RISalud
RD Apr 11, 2025