RT Journal Article
T1 Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration
A1 Aguareles, José
A1 Paraíso-Luna, Juan
A1 Palomares, Belén
A1 Bajo-Grañeras, Raquel
A1 Navarrete, Carmen
A1 Ruiz-Calvo, Andrea
A1 García-Rincón, Daniel
A1 García-Taboada, Elena
A1 Guzmán, Manuel
A1 Muñoz, Eduardo
A1 Galve-Roperh, Ismael
K1 Cannabinoid
K1 Huntingtin
K1 Neurodegeneration
K1 Neurogenesis
K1 PPAR
K1 Cannabinoides
K1 Proteína huntingtina
K1 Enfermedades neurodegenerativas
K1 Neurodegenerative diseases
K1 Neurogénesis
K1 Peroxisome proliferator-activated receptors
K1 Receptores activados del proliferador del peroxisoma
AB The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 receptors, which can elicit psychotropic effects, but other targets devoid of psychotropic activity, including CB2 and nuclear PPARγ receptors, can also be the target of specific cannabinoids.
PB BioMed Central Ltd.
YR 2019
FD 2019-03-08
LK http://hdl.handle.net/10668/3148
UL http://hdl.handle.net/10668/3148
LA en
NO Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, et al. Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration. Transl Neurodegener. 2019 Mar 8;8:9.
DS RISalud
RD Jul 30, 2025