%0 Journal Article
%A Gimenez-Miranda, Luis
%A Beltran-Romero, Luis
%A Leon-Jimenez, David
%A Stiefel, Pablo
%T PostCOVID effect on endothelial function in hypertensive patients: A new research opportunity
%D 2021
%@ 1524-6175
%U https://hdl.handle.net/10668/27797
%X SARS-CoV-2 is causing devastation both in human lives and economic resources. When the world seems to start overcoming the pandemics scourge, the threat of long-term complications of COVID-19 is rising. Reports show that some of these long-term effects may contribute to the main cause of morbimortality worldwide: the vascular diseases. Given the evidence of damage in the endothelial cells due to SARS-CoV-2 and that endothelial dysfunction precedes the development of arteriosclerosis, the authors propose to measure endothelial function around 6-12 months after acute disease in hypertensive patients, especially if they have other cardiovascular risk factors or overt vascular disease. The methods the authors propose are cost-effective and can be made available to any hypertension unit. These methods could be the "in vivo" assessment of endothelial function by flow mediated vasodilatation after ischemia by Laser-Doppler flowmetry and the measurement of plasma free circulating DNA and microparticles of endothelial origin.
%K circulating free DNA
%K endothelial dysfunction
%K endothelial microparticles
%K Laser-Doppler flowmetry
%K SARS CoV-2
%K Cell-free dna
%K Preeclampsia
%K Dysfunction
%K Correlate
%~