RT Journal Article T1 A Scoping Review Protocol to Explore the Use of Interleukin-1-Targeting Drugs for the Treatment of Dermatological Diseases: Indications, Mechanism of Action, Efficacy, and Safety. A1 Gomez-Garcia, Francisco A1 Ruano, Juan A1 Gay-Mimbrera, Jesus A1 Aguilar-Luque, Macarena A1 Sanz-Cabanillas, Juan L A1 Hernandez Romero, Jose L A1 Garcia-Nieto, Antonio Velez K1 Immune-mediated chronic inflammatory skin diseases K1 Interleukin-1-targeting drugs K1 PRISMA statement K1 Scoping review AB The interleukin (IL)-1 pathway has been identified as being involved in inflammatory and neoplastic skin diseases such as psoriasis, atopic dermatitis, neutrophilic dermatosis, melanoma, and squamous cell carcinoma. Drugs developed to target the IL-1 pathway are currently used to treat these pathologies, and although they are becoming more selective, they are not exempt from adverse events and high costs. Integrating the best research evidence with clinical experience and patient needs has been shown to improve care, health, and cost outcomes. This is because evidence-based guidelines rank interventions according to cost-effectiveness. However, evidence on this topic is scarce for several reasons. First, although randomized clinical trials currently provide the best evidence, they are not always available. Second, there are no secondary scientific studies that summarize the use of IL-1-targeting agents in dermatology. We therefore sought to develop an a priori protocol for broadly reviewing the available evidence on the use of IL-1-targeting drugs in the treatment of dermatological diseases. We used the latest methodology to perform a scoping review as described in the Joanna Briggs Institute manual. Developing and applying a methodology for evidence synthesis promotes reproducibility and increases the validity of secondary scientific investigations, making it the optimal strategy for scientifically synthesizing a broad field such as the indications for and the mechanisms of action, efficacies, safety, and costs of IL-1-targeting drugs in the treatment of dermatological diseases. Quantitative synthesis facilitates the detection of knowledge gaps and the identification of new questions that can be addressed through systematic reviews. We present an a priori protocol for exploring the available evidence on this topic. PB Springer SN 2193-8210 YR 2018 FD 2018-04-06 LK http://hdl.handle.net/10668/12319 UL http://hdl.handle.net/10668/12319 LA en NO Gómez-García F, Ruano J, Gay-Mimbrera J, Aguilar-Luque M, Sanz-Cabanillas JL, Hernández Romero JL, et al. A Scoping Review Protocol to Explore the Use of Interleukin-1-Targeting Drugs for the Treatment of Dermatological Diseases: Indications, Mechanism of Action, Efficacy, and Safety. Dermatol Ther (Heidelb). 2018 Jun;8(2):195-202 NO This work is supported, in part, by project ICI1400136 (which provided funding for J.R.), integrated into the National Plan of R ? D ? I 2008–2011, co-financed by the ISCIII-Subdireccion General de Evaluacion and European Regional Development Fund (ERDF), by project PIN-0316-2017-Consejerı´a de Salud Junta de Andalucía (J.R.)), and by grants PP13/009 (J.R.) and PP17/001 (J.G.-M.) of the Plan Propio de movilidad para investigadores delInstituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC). No funding was obtained from any pharmaceutical company. DS RISalud RD Apr 7, 2025