RT Journal Article
T1 Analysis of CXCL12 3 ' UTR G > A polymorphism in colorectal cancer
A1 Hidalgo-Pascual, M
A1 Galan, J J
A1 Chaves-Conde, M
A1 Ramírez-Armengol, J A
A1 Moreno, C
A1 Calvo, E
A1 Pelaez, P
A1 Crespo, C
A1 Ruiz, A
A1 Royo, J L
K1 Colorectal cancer
K1 SDF1-3'A
K1 rs1801157
K1 CXCL12
K1 3'UTR
K1 Quimiocina CXCL12
K1 Neoplasias del Colon
K1 Neoplasias del recto
K1 Análisis de supervivencia
AB Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.
PB Spandidos Publications
SN 1021-335X
YR 2007
FD 2007-12-01
LK http://hdl.handle.net/10668/1707
UL http://hdl.handle.net/10668/1707
LA en
NO Hidalgo-Pascual M, Galan JJ, Chaves-Conde M, Ramírez-Armengol JA, Moreno C, Calvo E, et al. Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer. Oncol Rep. 2007                         ; 18(6):1583-7
NO Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 18, 2025