%0 Journal Article
%A Hidalgo-Pascual, M
%A Galan, J J
%A Chaves-Conde, M
%A Ramírez-Armengol, J A
%A Moreno, C
%A Calvo, E
%A Pelaez, P
%A Crespo, C
%A Ruiz, A
%A Royo, J L
%T Analysis of CXCL12 3 ' UTR G > A polymorphism in colorectal cancer
%D 2007
%@ 1021-335X
%U http://hdl.handle.net/10668/1707
%X Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.
%K Colorectal cancer
%K SDF1-3'A
%K rs1801157
%K CXCL12
%K 3'UTR
%K Quimiocina CXCL12
%K Neoplasias del Colon
%K Neoplasias del recto
%K Análisis de supervivencia
%~