RT Journal Article
T1 Mind the nick.
A1 Wellinger, Ralf Erik
K1 DNA nick
K1 DNA replication
K1 R-loop
AB Genomic DNA can be prone to endogenous nicks. The contribution of DNA nicks to genome instability includes the breakage of double-stranded DNA due to single-stranded DNA nicking. A recent study mapped the genome-wide distribution of endogenous DNA nicks suggesting that transcription contributes to the formation and distribution of DNA nicks. R-loops are a byproduct of transcription, and nicked DNA seems to contribute to R-loop formation and vice versa. Here, I want discuss the possibility that the 3'OH of nicked DNA at R-loops could trigger unscheduled replication events.
YR 2018
FD 2018-12-28
LK http://hdl.handle.net/10668/13361
UL http://hdl.handle.net/10668/13361
LA en
DS RISalud
RD Apr 8, 2025