RT Journal Article
T1 Proton Pump Inhibitors and the Risk of Early Aseptic Loosening in Hip and Knee Arthroplasty.
A1 Tamimi, Iskandar
A1 Carnero, Pablo
A1 Bautista, David
A1 Gonzalez, David
A1 Rodrigo, Pablo
A1 Bravo, María Jose
A1 Gómez, Abel
A1 Tamimi, Faleh
A1 Garcia de Quevedo, David
K1 adult joint replacement
K1 arthroplasty
K1 aseptic loosening
K1 hip
K1 knee
K1 proton pump inhibitors
K1 revision surgery
AB The use of proton pump inhibitors (PPIs) has been associated with a higher risk of osteoporotic fractures and non-unions rates. However, the relation between the use of PPIs and the development of aseptic loosening in arthroplasty procedures has not been studied. The objective of this study is to analyze the relation between the use of PPIs, and the risk of early aseptic loosening in total knee arthroplasty (TKA) and total hip arthroplasty (THA). A nested case-control study was conducted on patients who were subjected THA or TKA in our center between 2010 and 2014. Cases were patients subjected to revision surgery due to early aseptic loosening during the study period. Cases were matched with controls who did not require any type of revision surgery by type of joint replacement (THA/TKA), gender, age (+/- 2 years), and follow-up time (±6 months). Odds Ratios were adjusted to potential confounders. The crude and adjusted ORs (95% CI) of undergoing revision surgery for aseptic loosening following primary total knee arthroplasty or total hip arthroplasty, were 6.25 (2.04-19.23) and 6.10 (1.71-21.73), respectively, for any use PPIs compared with non-users. Crude and adjusted ORs, were 11.6 (2.93-45.88) and 17.1 (2.41-121.66), respectively, for patients with a Proportion of Days Covered (PDC) for PPIs  These results suggest that PPIs should be used with caution in patients with TKA and THA, and that the use of these drugs should not be prolonged unless there was a justifiable indication. The use of PPIs and was associated with a higher risk of early aseptic loosening in patients subjected to THA and TKA.
SN 2151-4585
YR 2022
FD 2022-04-11
LK http://hdl.handle.net/10668/20239
UL http://hdl.handle.net/10668/20239
LA en
DS RISalud
RD Apr 5, 2025