RT Journal Article
T1 Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy.
A1 Resino, Salvador
A1 Seoane, Elena
A1 Pérez, Alicia
A1 Ruiz-Mateos, Ezequiel
A1 Leal, Manuel
A1 Muñoz-Fernández, Maria A
K1 Adulto
K1 Terapia Antirretroviral Altamente Activa
K1 Marcadores Biológicos
K1 Niño
K1 Estudios Transversales
K1 VIH
K1 Infecciones por VIH
K1 Linfocitos T
K1 Timo
K1 Carga Viral
K1 Adolescente
AB BACKGROUNDRecent advances in characterizing the immune recovery of HIV-1-infected people have highlighted the importance of the thymus for peripheral T-cell diversity and function. The aim of this study was to investigate differences in immune reconstitution profiles after highly active antiretroviral therapy (HAART) between HIV-children and adults.METHODSHIV patients were grouped according to their previous clinical and immunological status: 9 HIV-Reconstituting-adults (HIV-Rec-adults) and 10 HIV-Reconstituting-children (HIV-Rec-children) on HAART with viral load (VL) <or=400 copies/ml and CD4+ >or=500 cells/microL at least during 6 months before the study and CD4+ <or=300 cells/microL anytime before. Fifteen healthy-adults and 20 healthy-children (control subjects) were used to calculate Z-score values to unify value scales between children and adults to make them comparable.RESULTSHIV-Rec-children had higher T-cell receptor excision circles (TREC) and lower interleukin (IL)-7 levels than HIV-Rec-adults (p < 0.05). When we analyzed Z-score values, HIV-Rec-children had higher TREC Z-score levels (p = 0.03) than HIV-Rec-adults but similar IL-7 Z-score levels. Regarding T-cell subsets, HIV-Rec-children had higher naïve CD4+ (CD4+CD45RA hi+CD27+), naïve CD8+ (CD8+CD45RA hi+CD27+), and memory CD8+ (CD8+CD45RO+) cells/microl than HIV-Rec-adults, but similar memory CD4+ (CD4+CD45RO+) counts. HIV-Rec-children had lower naïve CD8+ Z-score values than HIV-Rec-adults (p = 0.05).CONCLUSIONOur data suggest that HIV-Rec-children had better thymic function than HIV-Rec-adults and this fact affects the peripheral T-cell subsets. Thus, T-cell recovery after HAART in HIV-Rec-adults could be the consequence of antigen-independent peripheral T-cell expansion while in HIV-Rec-children thymic output could play a predominant role in immune reconstitution.
PB BioMed Central
YR 2006
FD 2006-07-13
LK http://hdl.handle.net/10668/1706
UL http://hdl.handle.net/10668/1706
LA en
NO Resino S, Seoane E, Pérez A, Ruiz-Mateos E, Leal M, Muñoz-Fernández MA. Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy. BMC Infect Dis. 2006; 6:112
NO Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Mar 15, 2025