RT Journal Article
T1 Incidence of Hypersensitivity Reactions During Hemodialysis.
A1 Esteras, Raquel
A1 Martín-Navarro, Juan
A1 Ledesma, Gabriel
A1 Fernández-Prado, Raúl
A1 Carreño, Gilda
A1 Cintra, Melissa
A1 Cidraque, Ignacio
A1 Sanz, Ignacio
A1 Tarragón, Blanca
A1 Alexandru, Simona
A1 Milla, Mónica
A1 Astudillo, Elena
A1 Sánchez, Emilio
A1 Mas, Sebastian
A1 Tejeiro, Rafael Díaz
A1 Ortiz, Alberto
A1 Sánchez, Rafael
A1 González-Parra, Emilio
K1 Acute reaction
K1 Allergic reaction
K1 Dialyzer
K1 Hemodialysis
K1 Membrane
K1 Polynephron
K1 Polysulfone
AB A recent alert from Spanish health authorities warned of a higher incidence of reported hypersensitivity reactions to hemodialysis membranes with polysulfone, in the 2017 review of acute reactions to dialyzers found only published reports in the 21st century on polysulfone and its derivatives. The aim is to assess/evaluate the current incidence and characteristics of hypersensitivity reactions in hemodialysis patients. A retrospective multicentre study in 9 Spanish hospitals evaluated patients in whom a hypersensitivity reaction required a change in dialyzer membrane. A total of 37 patients out of 1561 (2.37%) had hypersensitivity reactions and clinical, epidemiological and analytical data were available for 33 patients (2.11%). The membranes involved were polysulfone (n=23), polynephron (n=8), polyethersulfone (n=1) and polyacrylonitrile (n=1). This distribution reflected the frequency of use of membranes in the participating dialysis units. The reactions were described as type A in 18 cases and type B in 15 cases. There were no significant differences between the two types in clinical symptoms, the composition of the membrane involved, the method of sterilization, the season, or the time during the session in which they occurred. The most frequent symptom was dyspnea/breathlessness (64% of reactions). Eosinophilia was common (74%). 54% of the reactions occurred within the first 30 minutes of hemodialysis, 64% occurred during the first year of dialysis, and 54% required discontinuation of dialysis session. Cellulose triacetate was used as an alternative dialyzer in 78% of the cases. The incidence of hypersensitivity reactions was in the range found in reports from 20 years ago and is observed associated with synthetic membranes, not just polysulfones. Cellulose triacetate appears to be a good alternative for these patients.
YR 2018
FD 2018-09-20
LK http://hdl.handle.net/10668/12969
UL http://hdl.handle.net/10668/12969
LA en
DS RISalud
RD Apr 10, 2025