TY  - JOUR
AU  - Jokela, Heli
AU  - Hakkarainen, Janne
AU  - Kätkänaho, Laura
AU  - Pakarinen, Pirjo
AU  - Ruohonen, Suvi T
AU  - Tena-Sempere, Manuel
AU  - Zhang, Fu-Ping
AU  - Poutanen, Matti
PY  - 2017
DO  - 10.1038/s41598-017-16618-5
UR  - http://hdl.handle.net/10668/11849
T2  - Scientific reports
AB  - HSD17B1 is a steroid metabolising enzyme. We have previously generated knockout mice that had the entire coding region of Hsd17b1 replaced with lacZ-neo cassette (Hsd17b1-LacZ/Neo mice). This resulted in a 90% reduction of HSD17B1 activity, associated...
LA  - en
PB  - Nature Publishing Group
KW  - 17-hydroxysteroid dehydrogenases
KW  - Alleles
KW  - Disease models, animal
KW  - Gene deletion
KW  - Animals
KW  - Gene expression
KW  - Genetic association studies
KW  - Genetic Loci
KW  - Glycosaminoglycans
KW  - Lysosomal storage diseases
KW  - Lysosomes
KW  - Male
KW  - Mice
KW  - Mucopolysaccharidosis III
KW  - Phenotype
TI  - Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.
TY  - research article
VL  - 7
ER  -