RT Journal Article
T1 Mediterranean Diet Supplemented With Coenzyme Q(10) Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women
A1 Lopez-Moreno, Javier
A1 Quintana-Navarro, Gracia M.
A1 Delgado-Lista, Javier
A1 Garcia-Rios, Antonio
A1 Alcala-Diaz, Juan F.
A1 Gomez-Delgado, Francisco
A1 Camargo, Antonio
A1 Perez-Martinez, Pablo
A1 Tinahones, Francisco J.
A1 Striker, Gary E.
A1 Perez-Jimenez, Francisco
A1 Villalba, Jose M.
A1 Lopez-Miranda, Jose
A1 Yubero-Serrano, Elena M.
K1 Oxidative stress
K1 Coenzyme Q(10)
K1 Mediterranean diet
K1 Age-related diseases
K1 Advanced glycation end products
K1 Oxidative stress
K1 Sevelamer carbonate
K1 Insulin-resistance
K1 Paradigm shift
K1 Plasma-levels
K1 Expression
K1 Disease
K1 Endproducts
K1 Glycotoxins
K1 Foods
AB Advanced glycation end products (AGEs) and oxidative stress are elevated with aging and dysmetabolic conditions. Because a Mediterranean (Med) diet reduces oxidative stress, serum AGEs levels, and gene expression related to AGEs metabolism in healthy elderly people, we studied whether supplementation with coenzyme Q(10) (CoQ) was of further benefit. Twenty participants aged >= 65 (10 men and 10 women) were randomly assigned to each of three isocaloric diets for successive periods of 4 weeks in a crossover design: Med diet, Med + CoQ, and a Western high-saturated-fat diet (SFA diet). After a 12-hour fast, volunteers consumed a breakfast with a fat composition similar to the previous diet period. Analyses included dietary AGEs consumed, serum AGEs and AGE receptor-1 (AGER1), receptor for AGEs (RAGE), glyoxalase I (GloxI), and estrogen receptor alpha (ER alpha) mRNA levels. Med diet modulated redox-state parameters, reducing AGEs levels and increasing AGER1 and GloxI mRNA levels compared with the SFA diet. This benefit was accentuated by adding CoQ, in particular, in the postprandial state. Because elevated oxidative stress/inflammation and AGEs are associated with clinical disease in aging, the enhanced protection of a Med diet supplemented with CoQ should be assessed in a larger clinical trial in which clinical conditions in aging are measured.
PB Oxford univ press inc
SN 1079-5006
YR 2018
FD 2018-03-01
LK http://hdl.handle.net/10668/18953
UL http://hdl.handle.net/10668/18953
LA en
DS RISalud
RD Apr 13, 2025