RT Journal Article
T1 Decreased Retinal Thickness in Type 1 Diabetic Children with Signs of Nonproliferative Diabetic Retinopathy
A1 Ruiz-Ocana, P.
A1 Espinoza Requena, P.
A1 Alonso-Ojembarrena, A.
A1 Alemany Marquez, P.
A1 Jimenez Carmona, S.
A1 Lechuga-Sancho, A. M.
K1 Optical coherence tomography
K1 Nerve-fiber layer
K1 Microvascular complications
K1 Risk-factors
K1 Adolescents
K1 Oct
K1 Variability
K1 Domain
K1 Reproducibility
K1 Prevalence
AB The retina functions as a neurovascular unit. How early vascular alterations affect neuronal layers remains controversial; early vascular failure could lead to edema increasing retinal thicknesses, but alternatively neuronal loss could lead to reduced retinal thickness. Objective. To evaluate retinal thickness in a cohort of pediatric patients with type 1 diabetes mellitus (PwT1DM) and to analyze differences according to the presence or absence of nonproliferative diabetic retinopathy (NPDR), poor metabolic control, and diabetes duration. Patients and Methods. We performed retinographies and optical coherence tomography (OCT) (TOPCON 3D1000 (R)) to PwT1DM followed at our center and healthy controls. Measurements of the control group served to calculate reference values. Results. 59 PwT1DM (age 12.51 +/- 2.59) and 22 healthy controls (age 10.66 +/- 2.51) volunteered. Only two PwT1DM, both adolescents with poor metabolic control, presented NPRD. Both showed decreased thicknesses and retinal volumes. The odds ratio of having decreased retinal thickness when signs of NPDR were present was 11.72 (95% IC 1.16-118.28; p = 0.036). Conclusions. PwT1DM with NPDR have increased odds of decreased retinal thicknesses and volumes. Whether these changes are reversible by improving metabolic control or not remains to be elucidated.
PB Hindawi ltd
SN 1687-8337
YR 2018
FD 2018-01-01
LK http://hdl.handle.net/10668/19067
UL http://hdl.handle.net/10668/19067
LA en
DS RISalud
RD Apr 12, 2025