RT Journal Article
T1 Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.
A1 Gutierrez-Bautista, Juan Francisco
A1 Rodriguez-Nicolas, Antonio
A1 Rosales-Castillo, Antonio
A1 Lopez-Ruz, Miguel Angel
A1 Martin-Casares, Antonia María
A1 Fernandez-Rubiales, Alonso
A1 Anderson, Per
A1 Garrido, Federico
A1 Ruiz-Cabello, Francisco
A1 Lopez-Nevot, Miguel Angel
K1 COVID-19
K1 HLA polymorphisms
K1 SARS-CoV-2
AB Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19. We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date. Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19. Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection.
PB Elsevier Ltd
YR 2021
FD 2021-08-05
LK http://hdl.handle.net/10668/22323
UL http://hdl.handle.net/10668/22323
LA en
NO Gutiérrez-Bautista JF, Rodriguez-Nicolas A, Rosales-Castillo A, López-Ruz MÁ, Martín-Casares AM, Fernández-Rubiales A, et al. Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients. J Microbiol Immunol Infect. 2022 Jun;55(3):421-427.
DS RISalud
RD Apr 5, 2025