%0 Journal Article
%A Hera, Belén de la
%A Varadé, Jezabel
%A García-Montojo, Marta
%A Alcina, Antonio
%A Fedetz, María
%A Alloza, Iraide
%A Astobiza, Ianire
%A Leyva, Laura
%A Fernández, Oscar
%A Izquierdo, Guillermo
%A Antigüedad, Alfredo
%A Arroyo, Rafael
%A Álvarez-Lafuente, Roberto
%A Vandenbroeck, Koen
%A Matesanz, Fuencisla
%A Urcelay, Elena
%T Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis.
%D 2014
%U http://hdl.handle.net/10668/1627
%X BACKGROUNDHuman endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts.METHODSA single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data.RESULTSSignificant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)].CONCLUSIONAssociation of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts.
%K Humanos
%K Esclerosis multiple
%K Retrovirus endógenos
%K Genoma
%K Cromosoma X
%K Grupo de ascendencia continental europea
%K España
%K Polimorfismo genético
%K Grupos étnicos
%K Estudios de cohortes
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