%0 Journal Article
%A Chianese, Giuseppina
%A Sirignano, Carmina
%A Benetti, Emanuele
%A Marzaroli, Vittoria
%A Collado, Juan A
%A de la Vega, Lauren
%A Appendino, Giovanni
%A Muñoz, Eduardo
%A Taglialatela-Scafati, Orazio
%T A Nrf-2 Stimulatory Hydroxylated Cannabidiol Derivative from Hemp (Cannabis sativa).
%D 2022
%U http://hdl.handle.net/10668/22593
%X A phytochemical analysis of mother liquors obtained from crystallization of CBD from hemp (Cannabis sativa), guided by LC-MS/MS and molecular networking profiling and completed by isolation and NMR-based characterization of constituents, resulted in the identification of 13 phytocannabinoids. Among them, anhydrocannabimovone (5), isolated for the first time as a natural product, and three new hydroxylated CBD analogues (1,2-dihydroxycannabidiol, 6, 3,4-dehydro-1,2-dihydroxycannabidiol, 7, and hexocannabitriol, 8) were obtained. Hexocannabitriol (8) potently modulated, in a ROS-independent way, the Nrf2 pathway, outperforming all other cannabinoids obtained in this study and qualifying as a potential new chemopreventive chemotype against cancer and other degenerative diseases.
%K Cannabidiol
%K Cannabinoids
%K Cannabis
%K NF-E2-related factor 2
%~