RT Journal Article
T1 Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain.
A1 Rodilla, Enrique
A1 Lopez-Carmona, Maria Dolores
A1 Cortes, Xavi
A1 Cobos-Palacios, Lidia
A1 Canales, Sergio
A1 Saez, Maria Carmen
A1 Campos-Escudero, Samara
A1 Rubio-Rivas, Manuel
A1 Diez-Manglano, Jesus
A1 Freire-Castro, Santiago J
A1 Vazquez-Piqueras, Nuria
A1 Mateo Sanchis, Elisabeth
A1 Pesqueira-Fontan, Paula Maria
A1 Magallanes-Gamboa, Jeffrey Oskar
A1 Gonzalez-Garcia, Andres
A1 Madrid-Romero, Victor
A1 Tamargo-Chamorro, Lara
A1 Gonzalez-Moraleja, Julio
A1 Villanueva-Martinez, Javier
A1 Gonzalez-Noya, Amara
A1 Suarez-Lombraña, Ana
A1 Gracia-Gutierrez, Anyuli
A1 Lopez-Reboiro, Manuel Lorenzo
A1 Ramos-Rincon, Jose Manuel
A1 Gomez-Huelgas, Ricardo
K1 COVID-19
K1 Arterial stiffness
K1 Blood pressure
K1 Heart failure
K1 Hypertension
K1 Pulse pressure
AB Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP)  <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.
PB Lippincott Williams & Wilkins
YR 2021
FD 2021-03-03
LK http://hdl.handle.net/10668/16876
UL http://hdl.handle.net/10668/16876
LA en
NO Rodilla E, López-Carmona MD, Cortes X, Cobos-Palacios L, Canales S, Sáez MC, et al. Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain. Hypertension. 2021 Mar 3;77(3):856-867
DS RISalud
RD Apr 11, 2025