RT Journal Article
T1 Cost-effectiveness analysis of molecular diagnosis by next-generation sequencing versus sequential single testing in metastatic non-small cell lung cancer patients from a south Spanish hospital perspective.
A1 de Alava, Enrique
A1 Pareja, María Jesús
A1 Carcedo, David
A1 Arrabal, Natalia
A1 García, José-Francisco
A1 Bernabé-Caro, Reyes
K1 Non-small cell lung cancer (NSCLC)
K1 cost-effectiveness
K1 molecular profiling
K1 next-generation sequencing
K1 oncogenic drivers
K1 sequential single testing
AB To assess the cost-effectiveness of using next-generation sequencing (NGS) compared to sequential single-testing (SST) for molecular diagnostic and treatment of patients with advanced non-small cell lung cancer (NSCLC) from a Spanish single-center perspective, the Hospital Universitario Virgen del Rocio (HUVR). A decision-tree model was developed to assess the alterations detection alterations and diagnostic cost in patients with advanced NSCLC, comparing NGS versus SST. Model inputs such as testing, positivity rates, or treatment allocation were obtained from the literature and the clinical practice of HUVR experts through consultation. Several sensitivity analyses were performed to test the robustness of the model. Using NGS for molecular diagnosis of a 100-patients hypothetical cohort, 30 more alterations could be detected and 3 more patients could be enrolled in clinical-trials than using SST. On the other hand, diagnostic costs were increased up to €20,072 using NGS instead of SST. Using NGS time-to-results would be reduced from 16.7 to 9 days. The implementation of NGS at HUVR for the diagnostic of patients with advanced NSCLC provides significant clinical benefits compared to SST in terms of alterations detected, treatment with targeted-therapies and clinical-trial enrollment, and could be considered a cost-effective strategy.
YR 2022
FD 2022-05-25
LK http://hdl.handle.net/10668/19681
UL http://hdl.handle.net/10668/19681
LA en
DS RISalud
RD Apr 5, 2025