RT Journal Article
T1 Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review.
A1 Benitez-Marin, Maria Jose
A1 Marin-Clavijo, Jesus
A1 Blanco-Elena, Juan Antonio
A1 Jimenez-Lopez, Jesus
A1 Gonzalez-Mesa, Ernesto
K1 Behavior
K1 Brain sparing
K1 Cognitive
K1 Executive functions
K1 Intrauterine growth restriction
K1 Motor
K1 Neurodevelopment
K1 Area de Gestión Sanitaria Sur de Córdoba
AB Fetal growth restriction (FGR) is a pregnancy complication. Multiple studies have connected FGR to poor cognitive development, behavior disorders, and academic difficulties during childhood. Brain sparing has traditionally been defined as an adaptive phenomenon in which the brain obtains the blood flow that it needs. However, this adaptive phenomenon might not have a complete protective effect. This publication aims to systematically review the consequences of brain redistribution on neurodevelopment in children who presented with placental intrauterine growth restriction. We performed a systematic review according to PRISMA guidelines. It included studies on intrauterine growth restriction or small-for-gestational-age (SGA) fetuses, which middle cerebral artery was measured, and neurodevelopment assessed during childhood. PUBMED and EMBASE databases were searched for relevant published studies. Of the 526 studies reviewed, only 12 were included. Brain sparing was associated with poor cognitive function and lower scores in IQ. Cerebral redistribution was related to better executive function and better behavior at 4 years old but not at 12 years old. We can assume that fetal brain sparing could not be a fully protective phenomenon. We could not find clinical differences in behavioral and executive functions because the results were heterogeneous. Some cognitive abilities could be affected in FGR brain sparing fetuses.
PB MDPI
SN 2227-9067
YR 2021
FD 2021-08-28
LK http://hdl.handle.net/10668/18550
UL http://hdl.handle.net/10668/18550
LA en
NO Benítez-Marín MJ, Marín-Clavijo J, Blanco-Elena JA, Jiménez-López J, González-Mesa E. Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review. Children (Basel). 2021 Aug 28;8(9):745
DS RISalud
RD Apr 8, 2025