RT Journal Article
T1 A 3-Biomarker 2-Point-Based Risk Stratification Strategy in Acute Heart Failure
A1 alvarez-Garcia, Jesus
A1 Garcia-Osuna, Alvaro
A1 Vives-Borras, Miquel
A1 Ferrero-Gregori, Andreu
A1 Martinez-Selles, Manuel
A1 Vazquez, Rafael
A1 Gonzalez-Juanatey, Jose R.
A1 Rivera, Miguel
A1 Segovia, Javier
A1 Pascual-Figal, Domingo
A1 Bover, Ramon
A1 Bascompte, Ramon
A1 Delgado, Juan
A1 Grau Sepulveda, Andres
A1 Bardaji, Alfredo
A1 Perez-Villa, Felix
A1 Zamorano, Jose Luis
A1 Crespo-Leiro, Marisa
A1 Sanchez, Pedro Luis
A1 Ordonez-Llanos, Jordi
A1 Cinca, Juan
A1 Spanish Heart Failure Network, 
K1 biomarker (BM)
K1 panel (C33)
K1 acute heart failure (AHF)
K1 risk stratification
K1 prognosis
K1 Brain natriuretic peptide
K1 Sensitivity troponin-t
K1 Family-member st2
K1 Prognostic value
K1 Term mortality
K1 Biomarkers
K1 Prediction
K1 Guidelines
K1 Score
K1 Hospitalization
AB Introduction and Objectives: Most multi-biomarker strategies in acute heart failure (HF) have only measured biomarkers in a single-point time. This study aimed to evaluate the prognostic yielding of NT-proBNP, hsTnT, Cys-C, hs-CRP, GDF15, and GAL-3 in HF patients both at admission and discharge.Methods: We included 830 patients enrolled consecutively in a prospective multicenter registry. Primary outcome was 12-month mortality. The gain in the C-index, calibration, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) was calculated after adding each individual biomarker value or their combination on top of the best clinical model developed in this study (C-index 0.752, 0.715-0.789) and also on top of 4 currently used scores (MAGGIC, GWTG-HF, Redin-SCORE, BCN-bioHF).Results: After 12-month, death occurred in 154 (18.5%) cases. On top of the best clinical model, the addition of NT-proBNP, hs-CRP, and GDF-15 above the respective cutoff point at admission and discharge and their delta during compensation improved the C-index to 0.782 (0.747-0.817), IDI by 5% (p
PB Frontiers media sa
YR 2021
FD 2021-10-22
LK https://hdl.handle.net/10668/25217
UL https://hdl.handle.net/10668/25217
LA en
DS RISalud
RD Apr 4, 2025