RT Journal Article
T1 Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance
A1 Tinahones, Francisco J
A1 Cardona Díaz, Fernando
A1 Rojo-Martínez, Gemma
A1 Almaraz, María de la Cruz
A1 Cardona, Isabel
A1 Vázquez-Mellado, J
A1 Garrido-Sánchez, Lourdes
A1 Collantes, E
A1 Soriguer Escofet, Federico
K1 OGTT
K1 Glucemia
K1 Colesterol
K1 HDL-Colesterol
K1 Prueba de Tolerancia a la Glucosa
K1 Insulina
K1 Resistencia a la Insulina
K1 Estrés Oxidativo
K1 Análisis de Regresión
K1 Triglicéridos
K1 Ácido úrico
K1 Uric acid
K1 Insulin resistance
K1 OGTT
K1 Triacylglycerol
AB Hyperuricaemia is one of the components of metabolic syndrome. Both oxidative stress and hyperinsulinism are important variables in the genesis of this syndrome and have a close association with uric acid (UA). We evaluated the effect of an oral glucose challenge on UA concentrations. The study included 656 persons aged 18 to 65 years. Glycaemia, insulin, UA and plasma proteins were measured at baseline and 120 min after an oral glucose tolerance test (OGTT). The baseline sample also included measurements of total cholesterol, triacylglycerol (TAG) and HDL-cholesterol. Insulin resistance was calculated with the homeostasis model assessment. UA levels were significantly lower after the OGTT (281.93 (sd 92.19) v. 267.48 (sd 90.40) micromol/l; P < 0.0001). Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Multiple regression analysis showed that the basal TAG levels, insulin at 120 min, glycaemia at 120 min and waist:hip ratio significantly predicted the variance in the UA difference (r2 0.077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels.
PB Cambridge University Press
SN 0007-1145
YR 2008
FD 2008-01
LK http://hdl.handle.net/10668/629
UL http://hdl.handle.net/10668/629
LA en
NO Tinahones Madueño FJ, Cardona Díaz F, Rojo-Martínez G, Almaraz MC, Cardona I, Vázquez-Mellado J, et al. Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. Br. J. Nutr.. 2008; 99(1):44-8
NO Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025