RT Journal Article
T1 Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis
A1 de Dios Caballero, Juan
A1 Dolores Pastor, Maria
A1 Vindel, Ana
A1 Maiz, Luis
A1 Yague, Genoveva
A1 Salvador, Carme
A1 Cobo, Marta
A1 Morosini, Maria-Isabel
A1 del Campo, Rosa
A1 Canton, Rafael
A1 GEIFQ Study Grp, 
K1 Clinical isolate
K1 Gene
K1 Mechanisms
K1 Infection
K1 Strain
AB Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.
PB Amer soc microbiology
SN 0066-4804
YR 2016
FD 2016-03-01
LK https://hdl.handle.net/10668/27280
UL https://hdl.handle.net/10668/27280
LA en
DS RISalud
RD Apr 12, 2025