TY  - JOUR
AU  - Garcia-Leon, Juan Antonio
AU  - Caceres-Palomo, Laura
AU  - Sanchez-Mejias, Elisabeth
AU  - Mejias-Ortega, Marina
AU  - Nuñez-Diaz, Cristina
AU  - Fernandez-Valenzuela, Juan Jose
AU  - Sanchez-Varo, Raquel
AU  - Davila, Jose Carlos
AU  - Vitorica, Javier
AU  - Gutierrez, Antonia
PY  - 2020
DO  - 10.3390/ijms21186867
UR  - http://hdl.handle.net/10668/3602
T2  - International Journal of Molecular Sciences
AB  - Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are...
LA  - en
PB  - MDPI
KW  - Human induced pluripotent stem cells (hiPSCs)
KW  - Disease modeling
KW  - Alzheimer’s disease
KW  - Microglia
KW  - Astrocytes
KW  - Oligodendrocytes
KW  - 3D cultures
KW  - Brain organoids
KW  - Células madre pluripotentes inducidas
KW  - Enfermedad de Alzheimer
KW  - Microglía
KW  - Astrocitos
KW  - Oligodendroglía
KW  - Organoides
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
KW  - Medical Subject Headings::Anatomy::Cells::Neuroglia::Astrocytes
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Culture Techniques
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discovery::Drug Evaluation, Preclinical
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Pluripotent Stem Cells::Induced Pluripotent Stem Cells
KW  - Medical Subject Headings::Anatomy::Cells::Neuroglia::Microglia
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells
KW  - Medical Subject Headings::Anatomy::Cells::Neuroglia::Oligodendroglia
KW  - Medical Subject Headings::Anatomy::Tissues::Organoids
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Microtubule-Associated Proteins::tau Proteins
TI  - Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease
TY  - review article
ER  -