RT Journal Article
T1 Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease
A1 Garcia-Leon, Juan Antonio
A1 Caceres-Palomo, Laura
A1 Sanchez-Mejias, Elisabeth
A1 Mejias-Ortega, Marina
A1 Nuñez-Diaz, Cristina
A1 Fernandez-Valenzuela, Juan Jose
A1 Sanchez-Varo, Raquel
A1 Davila, Jose Carlos
A1 Vitorica, Javier
A1 Gutierrez, Antonia
K1 Human induced pluripotent stem cells (hiPSCs)
K1 Disease modeling
K1 Alzheimer’s disease
K1 Microglia
K1 Astrocytes
K1 Oligodendrocytes
K1 3D cultures
K1 Brain organoids
K1 Células madre pluripotentes inducidas
K1 Enfermedad de Alzheimer
K1 Microglía
K1 Astrocitos
K1 Oligodendroglía
K1 Organoides
AB Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number of evidences have pointed towards glial cell dysfunction as one of the main causative phenomena implicated in AD pathogenesis. The complex disease pathology together with the lack of reliable disease models have precluded the development of effective therapies able to counteract disease progression. The discovery and implementation of human pluripotent stem cell technology represents an important opportunity in this field, as this system allows the generation of patient-derived cells to be used for disease modeling and therapeutic target identification and as a platform to be employed in drug discovery programs. In this review, we discuss the current studies using human pluripotent stem cells focused on AD, providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies.
PB MDPI
YR 2020
FD 2020-09-18
LK http://hdl.handle.net/10668/3602
UL http://hdl.handle.net/10668/3602
LA en
NO Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ et al. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. Int J Mol Sci. 2020 Sep 18;21(18):6867
DS RISalud
RD Apr 7, 2025