RT Journal Article
T1 Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation.
A1 Silva, Bryon
A1 Mantha, Olivier L
A1 Schor, Johann
A1 Pascual, Alberto
A1 Plaçais, Pierre-Yves
A1 Pavlowsky, Alice
A1 Preat, Thomas
K1 Astrocyte
K1 Long-term memory
K1 Metabolism
AB During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. Here we show that during starvation, neurons of the fly olfactory memory centre import and use ketone bodies (KBs) as an energy substrate to sustain aversive memory formation. We identify local providers within the brain, the cortex glia, that use their own lipid store to synthesize KBs before exporting them to neurons via monocarboxylate transporters. Finally, we show that the master energy sensor AMP-activated protein kinase regulates both lipid mobilization and KB export in cortex glia. Our data provide a general schema of the metabolic interactions within the brain to support memory when glucose is scarce.
PB Nature Publishing Group
YR 2022
FD 2022-02-17
LK http://hdl.handle.net/10668/19637
UL http://hdl.handle.net/10668/19637
LA en
NO Silva B, Mantha OL, Schor J, Pascual A, Plaçais PY, Pavlowsky A,et al. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Nat Metab. 2022 Feb;4(2):213-224.
DS RISalud
RD Jun 1, 2025