RT Journal Article
T1 Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
A1 Moreno-Navarrete, Jose Maria
A1 Lopez-Navarro, Eva
A1 Candenas, Luz
A1 Pinto, Francisco
A1 Ortega, Francisco J
A1 Sabater-Masdeu, Monica
A1 Fernandez-Sanchez, Manuel
A1 Blasco, Victor
A1 Romero-Ruiz, Antonio
A1 Fontan, Marina
A1 Ricart, Wifredo
A1 Tena-Sempere, Manuel
A1 Fernandez-Real, Jose M
K1 Ferroportin
K1 Ferritin
K1 Infertility
K1 In vitro fertilization
K1 Ovarian granulosa cells
K1 Sterility
K1 Uterine cervical cells
AB To explore the relationship between iron and infertility by investigating iron-related gene expression in granulosa and uterine cervical cells. Case-control study. Two tertiary hospitals. Two independent cohorts of fertile (n = 18 and n = 17) and infertile (n = 31 and n = 35) women. In vitro fertilization. Gene expression levels of ferritin light chain (FTL), ferritin heavy chain (FTH), transferrin receptor (TFRC), and ferroportin (SLC40A1) mRNA were analyzed in granulosa and cervical cells. In the first cohort, fertile and infertile women were similar in body mass index. Ferroportin mRNA levels were decreased in granulosa cells from infertile women in parallel with increased serum hepcidin levels. A positive association between ferroportin and TFRC mRNA, a gene associated with intracellular iron deficiency, was observed only in granulosa cells from fertile women. The major findings were replicated in a second independent cohort. Ferroportin mRNAs and circulating hepcidin identify a subset of infertile women and may constitute a target for therapy.
PB Elsevier
YR 2016
FD 2016-10-06
LK http://hdl.handle.net/10668/10603
UL http://hdl.handle.net/10668/10603
LA en
NO Moreno-Navarrete JM, López-Navarro E, Candenas L, Pinto F, Ortega FJ, Sabater-Masdeu M, et al. Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women. Fertil Steril. 2017 Jan;107(1):236-242
DS RISalud
RD Apr 12, 2025