TY - JOUR AU - Martins, Ana Paula AU - Marrone, Alessandro AU - Ciancetta, Antonella AU - Galán Cobo, Ana AU - Echevarría, Miriam AU - Moura, Teresa F AU - Re, Nazzareno AU - Casini, Angela AU - Soveral, Graça PY - 2012 DO - 10.1371/journal.pone.0037435 UR - http://hdl.handle.net/10668/829 T2 - PloS one AB - Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many physiological functions. Aquaporin-based modulator drugs are predicted to be of broad potential utility in the treatment of several... LA - en PB - Public Library of Science KW - Acuaporina 3 KW - Glicerol KW - Agua Corporal KW - Compuestos de Oro KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Porins::Aquaporins::Aquaglyceroporins::Aquaporin 3 KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Biological Transport::Cell Membrane Permeability KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discovery KW - Medical Subject Headings::Anatomy::Cells::Blood Cells::Erythrocytes KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Sugar Alcohols::Glycerol KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Gold Compounds KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Molecular Structure KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::PC12 Cells KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Protein Binding KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Hydroxides::Water KW - Medical Subject Headings::Organisms::Eukaryota::Animals TI - Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound. TY - research article ER -