TY - JOUR AU - Gonzalez-Rubio, Sandra AU - Linares, Clara I AU - Aguilar-Melero, Patricia AU - Rodriguez-Peralvarez, Manuel AU - Montero-Alvarez, Jose L AU - de la Mata, Manuel AU - Ferrin, Gustavo PY - 2016 DO - 10.1371/journal.pone.0160525 UR - http://hdl.handle.net/10668/10334 T2 - PloS one AB - The harmful effects of bile acid accumulation occurring during cholestatic liver diseases have been associated with oxidative stress increase and endothelial nitric oxide synthase (NOS-3) expression decrease in liver cells. We have previously reported... LA - en PB - Public Library of Science KW - Apoptosis KW - Carcinoma, Hepatocellular KW - Cyclin D1 KW - Down-Regulation KW - Genes, Reporter KW - Glycochenodeoxycholic acid KW - Hep G2 cells KW - Humans KW - Liver neoplasms KW - NG-nitroarginine methyl ester KW - Nitric oxide synthase type III KW - Oxidative stress KW - Promoter regions, genetic KW - Proto-oncogene proteins c-fos KW - Proto-oncogene proteins c-jun KW - Retinoids KW - Transcription factor AP-1 KW - Up-regulation TI - AP-1 Inhibition by SR 11302 Protects Human Hepatoma HepG2 Cells from Bile Acid-Induced Cytotoxicity by Restoring the NOS-3 Expression. TY - research article VL - 11 ER -