RT Journal Article
T1 Influence of pneumococcal vaccination on the hospitalization of healthy pediatric patients due to typical Community-Acquired Pneumonia
A1 Valdivielso Martínez, Ana Isabel
A1 Ramos Fernández, Jose Miguel
A1 Pérez Frías, Javier
A1 Moreno Pérez, David
K1 Pneumococcal conjugates vaccines
K1 Pneumonia in children
K1 Pediatrics
K1 Hospitalization
K1 Community-acquired infections
K1 Pneumococcal vaccines
K1 Pediatría
K1 Neumonía
K1 Hospitalizacion
K1 Infecciones comunitarias adquiridas
K1 Vacunas neumococicas
K1 Niño
K1 Adolescent
K1 Preescolar
K1 Estudios retrospectivos
AB IntroductionCommunity-Acquired Pneumonia (CAP) is one of the most frequent causes of hospital admission in children. Our objective is to measure the impact of the introduction of pneumococcal conjugate vaccines on the hospitalization of previously healthy children due to CAP.MethodFrom 2011 to 2016, a partially retrospective, prospective, and descriptive study was carried out on healthy pediatric patients (3 months–14 years old) with CAP, who required hospital admission. Clinical, epidemiological, and demographic characteristics were collected, and vaccination status was obtained from medical records.ResultsA total of 292 cases were included, with a mean age of 33.4 months, 54% males. There was a progressive and significant 42% decrease in the number of admissions each year, without significant changes in the annual percentage of parapneumonic pleural effusion (PPE). Fifty-six percent of patients were immunized with a pneumococcal conjugate vaccine (PCV). The percentage of children who were not vaccinated decreased by 14%, and the coverage with PCV-13 increased by 46%. This revealed a significant increase of PPE in vaccinated patients with PCV-7 (63%) compared with unvaccinated (45%) and with PCV-13 (57%), without association with the presence of severe PPE. Moreover, no significant differences in severity or hospital stay were observed in unvaccinated patients, compared to those who were vaccinated. In >2-year-olds, we observed a significant increase in PPE (59%) compared to 45% in younger children.ConclusionsThe increase in vaccination coverage with PCV-13 resulted in a decrease in hospitalizations due to CAP and PPE. Vaccination with PCV-7 is associated in our sample with an increase in PPE but not with severe PPE nor an increase in the hospital stay. There was an epidemiological shift of severe forms of pneumonia and empyema at later ages (>2 years).
PB Elsevier Ltd
SN 1201-9712
YR 2020
FD 2020-09
LK http://hdl.handle.net/10668/3469
UL http://hdl.handle.net/10668/3469
LA en
NO Valdivielso Martínez AI, Ramos Fernández JM, Pérez Frías J, Moreno Pérez D. Influence of pneumococcal vaccination on the hospitalization of healthy pediatric patients due to typical Community-Acquired Pneumonia. Int J Infect Dis. 2020 Sep;98:194-199.
NO International Journal of Infectious Diseases, official publication of the International Society for Infectious Diseases
DS RISalud
RD Jun 1, 2025